Our responses to Chemical Splashes


  • DIPHOTERINE®
  • Eyewash
  • Shower & Sprays
  • FAQ
  • Testimonies

The DIPHOTERINE® solution


In response to the mechanism of chemical burns, an efficient decontamination requires:


  • to remove the chemical from the surface to prevent further penetration
  • to stop polyvalently the six kinds of aggressive chemical reactions
  • to be able to stop the penetration of the aggressive product into the tissues.

1- Like the usual rinsing solutions, The DIPHOTERINE® solution is a liquid and therefore meets the need of rinsing the surface.


2- The DIPHOTERINE® solution contains a chelating and amphoteric molecule with at least one site able to stop the six kinds of possible reactions (acid, base, oxidation, reduction, solvatation, chelation).


Polyvalence is a crucial advantage of the DIPHOTERINE® solution.


Diphotérine®
reaction

 


3- The DIPHOTERINE® solution is hypertonic which allows to attract towards the outside the chemical that has yet penetrated into the tissues.


The combination of these three properties allows the DIPHOTERINE® solution to prevent any possible sequelae resulting from this kind of accident because it decontaminates the chemical splash completely, inside and outside the tissues, in a polyvalent way.


The DIPHOTERINE® solution is guaranteed to be phosphate-free.


Learn more about the DIPHOTERINE® solution»

The DIPHOTERINE® solution eyewash


In case of ocular chemical splash of a corrosive or irritant product, rinsing with the DIPHOTERINE® solution as soon as possible is crucial.


Available as wall-mounted stations or portable eyewashes, eyewashes must be installed in a place so close to the potential splash hazard that they can be triggered in the first minute following an accident.


SIEW Diphoterine®


The SIEW (for Sterilized Individual EyeWash) was specially intended for mobile staff units who can't have fixed equipment at their disposal.


The SIEW must be individually worn by staff in order to allow its use within the 10 first seconds after splash.


SIEW product characteristics

LMPE.DAS


The DIPHOTERINE® solution wall-mounted station LMDAS is a fixed and central rinsing spot that allows rinsing of body areas such as the face. It includes 2 LPMD DIPHOTERINE® solution bottles, 1 AFTERWASHII® solution bottle and 1 MINI Dap spray.


LMPE.DAS product characteristics

Also exists in an antifreeze version
LMPEGF.DAS product characteristics

LPM Diphoterine® LPM

The LPM DIPHOTERINE® solution portable eyewash is a 500 ml packaging which allows to perform ocular rinsing within the first minute following the accident. It may be installed next to a hazardous workstation or carried around in staff toolboxes.


LPM product characteristics


LMPE.DAS can be installed in the following conditions:
  • In laboratories,
  • In factories, next to hazardous workstations,
  • In storage premises,
  • Next to stripping baths,
  • Carried around by maintenance staff, in non hazardous areas,
  • In first-aid rooms, in order to perform additional rinsing, in case of late use on the accident scene…

Documents available via this link:

 

Rinsing skin with the DIPHOTERINE® solution


In case of cutaneous chemical splash of a corrosive or irritant product, rinsing with the DIPHOTERINE® solution as soon as possible is crucial.


DAP Diphoterine®

The DIPHOTERINE® solution DAP autonomous portable shower must be installed in a place so close to the potential splash hazard that they can be triggered in the first minute following an accident.


It allows the rinsing of a complete body, with intervention within the first minute following the accident.
The DAP can be protected and easily identifiable indoors if installed in a specific box or outdoors in a protective unit for extreme cold.


DAPD product characteristics

MINI DAP Sprays Diphoterine®

The DIPHOTERINE® solution sprays allow the decontamination of small cutaneous splashes.
There are two sizes of DIPHOTERINE® solution sprays, the use of which depends on the kind of potential splash and thus on the area to decontaminate:


  • a MICRO DAP (100 ml) allows the decontamination of a small body part such as the hand or the cheek,
  • a MINI DAP (200 ml) allows the decontamination of the face or the thigh.

In case of larger splashes, it's better to use a The DIPHOTERINE® solution DAP.


MINI DAP product characteristics
MICRO DAP product characteristics


The DIPHOTERINE® solution sprays can be used in the following conditions:
  • In unloading areas,
  • In laboratories,
  • Next to surface treatment baths,
  • Carried around by maintenance staff, in non hazardous areas,
  • In first-aid rooms, in order to perform additional rinsing, in case of late use on the accident scene…

Documents available via this link:


Learn more about sprays»

Frequently Asked Questions


Here is the list of the most frequently asked questions about the DIPHOTERINE® solution.


  1. What is the DIPHOTERINE® solution?

    • The DIPHOTERINE® solution is a polyvalent, hypertonic, amphoteric, chelating agent for emergent decontamination of eye/skin chemical splashes. It is supplied as a sterile solution in water. When utilized during the initial minute following the splash and with the total quantity delivered from the application device, external decontamination with the DIPHOTERINE® solution has the objective of preventing or minimizing the appearance of lesions, and thus the risks of sequelae.
  2. What is the mechanism of action of the DIPHOTERINE® solution ?

    • The DIPHOTERINE® solution has active binding sites and as an amphoteric compound can bind chemically opposite compounds such as acids-bases, oxidizers-reducing agents, etc. It is a chelating compound. Its hypertonicity also aids in setting up an osmotic gradient which can stop the penetration of chemicals and assist in removing chemicals which have already penetrated.
  3. Why is the DIPHOTERINE® solution hypertonic ?

    • The DIPHOTERINE® solution is hypertonic in order to stop and avoid the penetration of the chemicals into the tissues. An hyperosmolar pressure creates a flux from the inside to the outside of the tissues: the chemicals are then pulled out from the inside of the tissues to their surface, skin or eye. With an hypertonic solution, the decontamination is then accelerated.
  4. Why is the DIPHOTERINE® solution amphoteric ?

    • An amphoteric compound is one capable of binding (and thus decontaminating) opposing chemical substances such as acids-bases or oxidizers-reducing agents. The rinsing with an amphoteric solution such as the DIPHOTERINE® solution allows a quick return to a physiological state and has the objective of securing the result of the rinsing.
  5. Is the DIPHOTERINE® solution a chelator ?

    • Yes, the DIPHOTERINE® solution is a chelator. It can chelate radionuclides such as strontium, cobalt, cesium or uranium. It can chelate anions such as oxalate, but doesn’t chelate calcium or magnesium.
  6. What are the demonstrated advantages of the DIPHOTERINE® solution regarding efficacy ?

    • The DIPHOTERINE® solution is polyvalent. As such, it is effective against a very wide range of chemicals/chemical groups (over 600 tested in vitro), including acids, bases, oxidizers, reducing agents, irritants, solvents, and lacrimators. It is thus a logical choice for use in decontaminating unknown chemical splashes.
  7. What is the toxicity of the DIPHOTERINE® solution? Does it lack toxicity/irritancy/ sensitization potential ?

    • The DIPHOTERINE® solution is non-toxic (LD50 > 2,000 mg/kg oral/skin in experimental animals). No toxicity has been reported in human workplace use despite the fact that the manufacturer has had an active pharmacovigilance program.
    • No mutagenic effect was detected by Ames test.
    • The DIPHOTERINE® solution itself and its reaction residues with strong acid and base are not irritating in rabbit eyes. It was not irritating to the eyes of normal human volunteers. No adverse effects have been reported following its use in industrial accidents. In guinea pigs, the DIPHOTERINE® solution was not a skin sensitizer.
    • In ecotoxicity tests, it was non-toxic to standard test organisms.
  8. For which uses is the DIPHOTERINE® solution recommended ?

    • The DIPHOTERINE® solution is recommended for skin/eye decontamination of nearly all chemical substances, such as acids, bases, oxidizers, reducing agents, and solvents.

  9. What are the limitations of the DIPHOTERINE® solution?
    a) Is the DIPHOTERINE® solution active against all chemical products ?
    b) Is its efficacy in the first few minutes the same after a long delay ?

    • a) The DIPHOTERINE® solution has limited efficacy on hydrofluoric acid (HF) exposures or fluorides in an acidic milieu. A derivative product, the HEXAFLUORINE® solution, is available and efficacious for HF exposures.
      The DIPHOTERINE® solution is not recommended for white phosphorous decontamination.
    • b) Rinsing with the DIPHOTERINE® solution is most efficacious when used as soon as possible after the skin/eye chemical exposure (within the first minute). The longer the delay to use the DIPHOTERINE® solution, the less likely it is to prevent or decrease the severity of the burn. Delayed use of the DIPHOTERINE® solution can stop the action of the chemical product and specific treatment will be necessary to improve wound healing.
      Once the exposed skin/eye tissue cells have been destroyed by the splashed chemical, the DIPHOTERINE® solution can no longer be efficacious.
  10. Is the DIPHOTERINE® solution useful for thermal burns ?

    • The DIPHOTERINE® solution is not currently recommended for first aid response to purely thermal burns. There are proposals to test it for this use. Combined thermal/chemical burns from chemicals used at high temperatures may well benefit from initial DIPHOTERINE® solution decontamination.
    • It is recommended to first decontaminate the chemical burn and then to treat the thermal burn.
  11. Can you use the DIPHOTERINE® solution to decontaminate dusts and chemically inert particulates, including metals ?

    • Because it is a chelator, the DIPHOTERINE® solution can be used to decontaminate metals (as well as radionuclides such as uranium-238, cesium-137, strontium/yttrium-90, and cobalt-60). For dusts and other chemically inert substances, the DIPHOTERINE® solution is supplied as a sterile water-based solution and thus has dilutional and mechanical rinsing activity. However, AFTERWASHII®, a comfort isotonic rinsing solution, is more appropriated for dusts and other chemically inert substances.
  12. Can you utilize the DIPHOTERINE® solution to decontaminate chemically active solids (i.e., sodium hydroxide, potassium hydroxide, etc.)?

    • The DIPHOTERINE® solution can be used to efficiently rinse solid active chemicals. Case reports have been described for pellets of sodium hydroxide following an eye exposure.
      The DIPHOTERINE® solution rinsing allows dilution of the pellets and, at the same time, to neutralize them, avoiding or stopping the chemical burn, depending on the contact time.
      The use of the DIPHOTERINE® solution is not appropriated for white phosphorous exposures.
  13. What happens if the DIPHOTERINE® solution is used when there hasn’t been a chemical exposure ?

    • Nothing. The DIPHOTERINE® solution is non-toxic and not irritating. It is not a sensitizer.
  14. Can the DIPHOTERINE® solution be used for caustic ingestions ?

    • The DIPHOTERINE® solution is being studied for decontamination of caustic ingestions in a pig model. Preliminary data indicate that it can be efficacious in this setting. It is not currently recommended for this purpose in humans. The DIPHOTERINE® solution is non-toxic as the oral LD50 is greater than 2000 mg/Kg.
  15. Can you decontaminate with water or normal saline before or after the DIPHOTERINE® solution? How do you use the DIPHOTERINE® solution?

    • In INRS studies, it was found that using water or normal saline either before or after the DIPHOTERINE® solution resulted in a worse outcome than if the DIPHOTERINE® solution was used alone. Theoretically, this is because using water or saline first delays the use of the active decontamination compound and using water or saline after the DIPHOTERINE® solution washes the active decontamination compound off the skin or out of the eye, preventing it from exerting its full effect.
  16. How do you utilize the DIPHOTERINE® solution in an optimal manner? Is it necessary to use the entire container ?

    • The DIPHOTERINE® solution is optimally utilized as soon as possible after the skin/eye chemical exposure and in sufficient volume. Workers/rescuers must be trained to use the entire volume of the appropriate size container. Because the DIPHOTERINE® solution very rapidly relieves pain once decontamination is started, the use of the total appropriate volume must be an important and frequently emphasized subject of worker/rescuer training.
  17. When should the DIPHOTERINE® solution be used ?

    • The DIPHOTERINE® solution should be used as soon as possible after nearly all skin/eye chemical splashes, with the exception of hydrofluoric acid (HF) splashes when the HEXAFLUORINE® solution should be used instead.
    • Because it is active against a very wide variety of chemical substances, the DIPHOTERINE® solution is particularly well-suited for use with unknown chemical exposures.
  18. Is the DIPHOTERINE® solution a medication ?

    • No. The DIPHOTERINE® solution has no physiological action on the eye or the skin.

      It is registered as a Medical Device in Europe.
  19. What are PREVOR’s other products ?

    • The HEXAFLUORINE® solution, a derivative of the DIPHOTERINE® solution, for the decontamination of skin/eye splashes due to hydrofluoric acid or fluorides in an acidic environment.
    • AFTERWASHII® is a comfort rinsing solution, isotonic to the tears. It can be used after the DIPHOTERINE® or HEXAFLUORINE® solutions rinsing to return to a physiological state or directly to rinse chemically inert dusts.
    • The TRIVOREX® powder is a solid material for absorption and active decontamination of a wide variety of chemical products spilled in the workplace or environment (not for use on humans).
    • As PREVOR Laboratory specializes in chemical risks,
      - books are published and available in French on Chemical risk and Health assessment, solvent prevention, MSDS interpretation and organization,

      - Training sessions are regularly organized in Paris for all prevention workers and specialists, on evaluation and prevention of chemical risks at the workplace.
  20. Why is there a shelf-life of two years ?

    • The 2-year shelf-life is to ensure :

      - that the product is replaced before it loses its sterility
      - that the washing solution conserves all of its properties
      - that the dispenser remains functional and retains optimal reliability for the end users
  21. Is there a gel form of the DIPHOTERINE® solution?

    • A gel form of the DIPHOTERINE® solution has been produced and is undergoing testing for a variety of potential uses, especially for esophago-gastrointestinal burns. It is not currently commercially available.
  22. What can you do with the DIPHOTERINE® solution after utilization ? [How can you dispose of the used DIPHOTERINE® solution ?]

    • The DIPHOTERINE® solution neutralizes the splashed chemical actively. It and its strong caustic decontamination residues are non-toxic and not ecotoxic. Used DIPHOTERINE® solution can be disposed of in the sanitary sewer system (unlike water decontamination solutions which will still have active chemical(s) present and should be disposed of as hazardous waste).
  23. What is the purpose of the HEXAFLUORINE® solution?

    • The HEXAFLUORINE® solution is a derivative of the DIPHOTERINE® solution specifically designed to rinse hydrofluoric acid eye/skin splashes and bind and neutralize both the H+ corrosive ions and F- toxic ions of hydrofluoric acid (HF).
      The HEXAFLUORINE® solution can also decontaminate eye/skin splashes due to fluorides in an acidic environment.
  24. What is the purpose of the AFTERWASHII® solution supplied with the DIPHOTERINE® solution in the wall-mounted eye decontamination station ?

    • The AFTERWASHII® assists in restoring the normal physiological state of the cornea after the DIPHOTERINE® solution decontamination. It is also designed for rinsing of chemical inert dusts.
  25. Is the eyebath used in the Prevor eyewash products a Morgan lens ?

    • PREVOR put its system of patented eye washes on the market in order to fulfil various requirements, in particular those related to the principle of emergency washing in the workplace:

      • To allow any victim to begin washing alone;
      • To allow the victim to correctly open the eye in order to make an effective washing;
      • To allow continuous and uniformly distributed washing of the cornea surface.

      The possibility of using the Morgan lens had been considered but dismissed, following various tests showing:

      • The difficulty of installing the lens in emergency situations, where the intervention time is limited;
      • A washing insufficiently uniform to be effective and a reproducible in all cases.

      It is for these reasons that PREVOR conceived, developed and patented its own system of a specific eyebath.

  26. Could a Morgan lens be installed on a PREVOR eyewash ?

    • The Morgan lens device is in particular designed to deliver the washing solution in the absence of medical personnel. This device could thus have an advantage in the case of a patient with multiple injuries or for the medical management of a large number of patients.
      However, the ophthalmologists consulted do not recommend the use of the Morgan lens to carry out ocular washing following a chemical splash because the result is not likely to be sufficiently homogeneous. It has indeed already been noted that when the Morgan lens is used, the washing fluid follows the channels and that created zones which were not irrigated by the instilled solution. However, to be effective in the washing of a chemical projection, it is necessary to irrigate the totality of the cornea and the conjunctival cul-de-sacs. We thus believe that the Morgan lens cannot guarantee the same advantages as manual washing carried out carefully by a specialist.

      Nota :
      Description of the Morgan lens:
      Tube connected to a perforated lens.
      Diameter of the tube < 2 mm
      Polystyrene lens glued to a tube.

      Ophthalmologists consulted:
      Dr Norbert Schrage, Clinique Ophtalmologique de Merheim
      Dr Harold Merle, Centre Hospitalier de Fort de France

  27. Should anaestesics drops be administered before using the DIPHOTERINE® solution?

    • The DIPHOTERINE® solution, which acts directly on the chemical, permits a quick reduction in the sensation of pain. The anaesthetic is thus, in practice, often of no use. Its possible use in the protocol of certain companies or in a hospital environment under medical ophthalmologic supervision could have only a complementary synergistic effect.

Testimonies


List of testimonies for the DIPHOTERINE® solution


Orange Marine, France


US and French warships


Chemical splashes risks essentially happen on the general service department, machine department, deck maintenance operations, where technicians worked.
Thanks to the implementation of washing station with DIPHOTERINE® solution cloth to risks area, on the 13 accidents happened (in 2 years), no ocular complications were noticed and no secondary specialist (specifically ophthalmologist) treatment was needed.


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HABITATION TRIANON, Martinique



An employee received an eye splash of a corrosive alkaline cleaner, diluted at 10%. Despite of the chemical dilution, pain was prompt and acute. Thanks to the use of DIPHOTERINE® solution, no secondary care nor sick leave were necessary.


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THOMSON AIRWAYS, UK


logo THOMSON AIRWAYS


DIPHOTERINE® solution's use on phosphate ester based hydraulic fluid's ocular splashes, is associated with good outcome, particularly in regard of a pain decrease.


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LONZA, UK


logo LONZA


Since the introduction of DIPHOTERINE® solution and its use as first aid in cases of skin or eye splashes, "no member of staff working for Lonza has been left with any lasting effects from chemical contact".


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List of testimonies for the DIPHOTERINE® solution