Diphoterine® is non-toxic (LD50 > 2,000 mg/kg oral/skin in experimental animals). No toxicity has been reported in human workplace use despite the fact that the manufacturer has had an active pharmacovigilance program.
No mutagenic effect was detected by Ames test.
Diphoterine® itself and its reaction residues with strong acid and base are not irritating in rabbit eyes. It was not irritating to the eyes of normal human volunteers. No adverse effects have been reported following its use in industrial accidents. In guinea pigs, Diphoterine® was not a skin sensitizer.
In ecotoxicity tests, it was non-toxic to standard test organisms.
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