Diphotérine® was evaluated for its sensitization potential in the guinea pig with primary induction (day 1, intra dermal injection), sensitization (day 9, topical application), and challenge (day 22, topical application). No irritation was noted at 24 and 48 hours in negative controls and in animals. Diphotérine® showed no allergenicity reaction after 24 and 48 hours. Diphotérine® appears to have no sensitizing capacity in the guinea pig.

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