Ocular burns due to bases : Comparison of human and experimental clinical data about the intraocular penetration of ammonia. Is there a delay for the external ocular rinsing during the treatment of serious ocular burns due to bases ?
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This work compares the data of a clinical prospective study and the experimental data about the ocular burns due to ammonia. The notion of delay for an ocular rinsing is underlined. A serie of in vivo experiments is carried out to comfort this data study, which shows that a rinsing after more than 30 minutes would have little effect as the return to the physiological pH was quasi re-established by itself. Paradoxically, a rinsing in the ten first minutes would have a beneficial effect. The study proves that an early rinsing with Diphotérine® entails the absence of a stromal oedema and a significant decrease of the intraocular pH that is not noticed with a rinsing with water or physiological serum.
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